DSPTCH hand-makes bags here in the USA and the Travel Pack is a great example of the kind of extremely durable designs they put together.
Other Bags to Check Out:
The X25 from RiutBag is an utterly functional travel and daily conversion backpack that also has an important security feature.
The Guide Pack from Tom Bihn is a bag geek's boner pill. It's classic design and exceedingly excellent manufacturing make it more like an heirloom than a bag. But this bag also performs great as a travel bag!
The Tortuga Setout Duffel is affordable and really durable duffel luggage built with tech organization, a security pocket, a shoe compartment, laptop storage and extremely ample exterior access.
The Headway MLC (Maximum Legal Carry-on) from Patagonia is a very functional gear bag that works better as a duffel due to it's uncomfortable (but hideable!) backpack straps.
The Subterra backpack from Thule is designed to be a minimal travel bag with room for both your tech needs, daily needs and weekend travel needs.