After the success of their killer duffel bag, Pakt partnered with Chase Reeves to design a modern travel backpack for both pro travelers and weekend warriors alike. Lots of external access, solid aesthetics, perfect carry-on size, organized without overcomplicating things. view bag
Lots of organization for the little stuff in the main organization panel. Also features dual water bottle pockets, laptop and tablet pockets, quick access pocket.
Two large compartments, each with simple internal organization. TONS of capacity in the 40L version (but that one can look really big on people shorter than 6ft).
The Outbreaker backpack from Tortuga is a solid 1-bag travel pick. I personally prefer the less bulky (and more spacious) experience of traveling with the Tortuga Setout, so be sure to check out that bag too. This Outbreaker, however, has quite a bit more padding and protection around the entire bag, so if you know you'll have delicate stuff inside you may prefer this one. view bag
Totally customizable and removable inner organization. Can all be removed and makes a great daily carry bag (or leave some in and customize for how you carry).
The Duffelpack from Peak Design expands from 45L to 65L (a little too large for carry-on on most airlines), has backpack straps that hide away, is made of weatherproof material and is a durable and organized companion for LOTS of different kinds of adventures. view bag